Bret

I don't think so. I did the brakes on my wife's Integra and my 240SX, both of which had ABS. Other than insignificant differences, they seemed pretty much the same as any non-ABS car that I have done. However, I don't have any experience on the S2000 brakes yet.

JDMwhore

There are really no sensors to worry about when changing pads. Hondas are one of the easiest cars to change pads on. The fronts require you to remove 2 bolts, one holding the brakeline to the shock the other is the top bolt on the caliper. The caliper will then swing down an open. You can use a C clamp or a LARGE pair of pliers to push in the front piston, on the rear use a 3/4 drive extension in the middle of the cross to rotate it inward. Have fun not very difficult at all.